The short answer
Duloxetine has no single cash price. Your total depends on the exact product, pharmacy, quantity, insurance, and offer. The CMS numbers below are pharmacy acquisition benchmarks—not patient prices.
Published pharmacy prices · Cash pay
Duloxetine prices at Cost Plus Drugs
Compare available sources with prescription price search
Selected generic tablet and capsule offers from one mail-order pharmacy. These are dated pharmacy estimates, separate from CMS acquisition benchmarks. We have not compared the whole market or verified your insurance benefit.
Checked . Use these observations only before ; confirm the price at checkout.
No current in-stock price observations are available for the selected products. Check the pharmacy directly.
| Exact product / quantity | Medication + dispensing | Shipping | Total with shipping |
|---|---|---|---|
| Duloxetine Delayed Release (DR) 20mgDelayed Release Capsule · 30 capsules · Generic | $5.92Medication $0.92 Dispensing $5.00 | $5.25 | $11.17Source-reported total |
| Duloxetine Delayed Release (DR) 20mgDelayed Release Capsule · 60 capsules · Generic | $6.84Medication $1.84 Dispensing $5.00 | $5.25 | $12.09Subtotal + source shipping fee |
| Duloxetine Delayed Release (DR) 20mgDelayed Release Capsule · 90 capsules · Generic | $7.76Medication $2.76 Dispensing $5.00 | $5.25 | $13.01Subtotal + source shipping fee |
| Duloxetine Delayed Release (DR) 30mgDelayed Release Capsule · 30 capsules · Generic | $5.89Medication $0.89 Dispensing $5.00 | $5.25 | $11.14Source-reported total |
| Duloxetine Delayed Release (DR) 30mgDelayed Release Capsule · 60 capsules · Generic | $6.77Medication $1.77 Dispensing $5.00 | $5.25 | $12.02Subtotal + source shipping fee |
| Duloxetine Delayed Release (DR) 30mgDelayed Release Capsule · 90 capsules · Generic | $7.66Medication $2.66 Dispensing $5.00 | $5.25 | $12.91Subtotal + source shipping fee |
| Duloxetine Delayed Release (DR) 40mgDelayed Release Capsule · 30 capsules · Generic | $23.77Medication $18.77 Dispensing $5.00 | $5.25 | $29.02Source-reported total |
| Duloxetine Delayed Release (DR) 40mgDelayed Release Capsule · 60 capsules · Generic | $42.54Medication $37.54 Dispensing $5.00 | $5.25 | $47.79Subtotal + source shipping fee |
| Duloxetine Delayed Release (DR) 40mgDelayed Release Capsule · 90 capsules · Generic | $61.30Medication $56.30 Dispensing $5.00 | $5.25 | $66.55Subtotal + source shipping fee |
| Duloxetine Delayed Release (DR) 60mgDelayed Release Capsule · 30 capsules · Generic | $6.47Medication $1.47 Dispensing $5.00 | $5.25 | $11.72Source-reported total |
| Duloxetine Delayed Release (DR) 60mgDelayed Release Capsule · 60 capsules · Generic | $7.93Medication $2.93 Dispensing $5.00 | $5.25 | $13.18Subtotal + source shipping fee |
| Duloxetine Delayed Release (DR) 60mgDelayed Release Capsule · 90 capsules · Generic | $9.40Medication $4.40 Dispensing $5.00 | $5.25 | $14.65Subtotal + source shipping fee |
Listed products were marked in stock when checked. A displayed shipping total is for one medication; do not add it repeatedly when comparing a combined order. Delivery eligibility, taxes if applicable, and the final checkout amount must be confirmed with the pharmacy.
Product links open the pharmacy’s listing to confirm the offer. This selection excludes packaged bottles, granule boxes, and products whose quantity units we cannot safely match.
Check current Cost Plus Drugs listings · How we collect pharmacy prices
International price references
Canada: Ontario Drug Benefit Formulary (CAD) · United Kingdom: NHS medication reimbursement reference (per pack) (GBP) · France: France BDPM public pack prices (EUR) · Sweden: Sweden TLV pharmacy selling prices (SEK) · Denmark: Denmark Medicinpriser retail prices (DKK). Amounts retain each source’s pricing basis and currency. Individual reimbursement and product equivalence are not calculated.
Before you compare Duloxetine
Include the full delayed-release description and strength when requesting a quote. Match the quantity on the prescription.
Duloxetine acquisition-cost reference
One representative NDC per description. Values retain five decimal places so low per-unit costs do not round to zero. EA means “each”; confirm the dispensing unit and package with your pharmacist.
Snapshot retrieved 2026-10-29. Individual record dates appear below.
| Product description / NDC | NADAC per unit | Unit | As of |
|---|---|---|---|
| duloxetine hcl dr 120 mg capNDC 52427079130 · Generic | $5.66007 | EA | |
| duloxetine hcl dr 20 mg capNDC 00228289006 · Generic | $0.11789 | EA | |
| duloxetine hcl dr 30 mg capNDC 00228289103 · Generic | $0.09941 | EA | |
| duloxetine hcl dr 40 mg capNDC 27241016430 · Generic | $1.21471 | EA | |
| duloxetine hcl dr 60 mg capNDC 00228289203 · Generic | $0.13680 | EA | |
| duloxetine hcl dr 90 mg capNDC 52427091330 · Generic | $5.65167 | EA |
Original CMS dataset · Download this reference as JSON · How we select records
CMS lists the underlying NADAC data as public domain. This designation applies to the CMS data, not the accompanying RxCompare articles or site design.
Acquisition benchmark history
Observed CMS acquisition costs for pharmacies, not prices patients pay. We compare only the same NDC, description, classification, and unit. No retail savings are inferred. Archive, downloads, and history methodology.
duloxetine hcl dr 120 mg cap · $0.00000 per EA change since 2026-10-21
NDC 52427079130 · EA · 2 source dates. Missing observations are not interpolated.
duloxetine hcl dr 20 mg cap · $0.00000 per EA change since 2026-10-21
NDC 00228289006 · EA · 14 source dates. Missing observations are not interpolated.
| Source date | First retrieved | USD per EA | Snapshot |
|---|---|---|---|
| 2026-01-28 | 2026-10-19 | $0.11613 | JSON |
| 2026-02-25 | 2026-10-19 | $0.12022 | JSON |
| 2026-03-25 | 2026-10-19 | $0.12470 | JSON |
| 2026-04-29 | 2026-10-19 | $0.13055 | JSON |
| 2026-05-27 | 2026-10-19 | $0.12772 | JSON |
| 2026-06-24 | 2026-10-19 | $0.12268 | JSON |
| 2026-07-29 | 2026-10-19 | $0.11612 | JSON |
| 2026-08-26 | 2026-10-19 | $0.11726 | JSON |
| 2026-09-16 | 2026-09-22 | $0.11726 | JSON |
| 2026-09-30 | 2026-10-19 | $0.11867 | JSON |
| 2026-10-07 | 2026-10-07 | $0.11867 | JSON |
| 2026-10-14 | 2026-10-15 | $0.11867 | JSON |
| 2026-10-21 | 2026-10-22 | $0.11789 | JSON |
| 2026-10-28 | 2026-10-29 | $0.11789 | JSON |
duloxetine hcl dr 30 mg cap · $0.00000 per EA change since 2026-10-21
NDC 00228289103 · EA · 14 source dates. Missing observations are not interpolated.
| Source date | First retrieved | USD per EA | Snapshot |
|---|---|---|---|
| 2026-01-28 | 2026-10-19 | $0.07811 | JSON |
| 2026-02-25 | 2026-10-19 | $0.07822 | JSON |
| 2026-03-25 | 2026-10-19 | $0.08485 | JSON |
| 2026-04-29 | 2026-10-19 | $0.09517 | JSON |
| 2026-05-27 | 2026-10-19 | $0.09840 | JSON |
| 2026-06-24 | 2026-10-19 | $0.10077 | JSON |
| 2026-07-29 | 2026-10-19 | $0.10141 | JSON |
| 2026-08-26 | 2026-10-19 | $0.10584 | JSON |
| 2026-09-16 | 2026-09-22 | $0.10584 | JSON |
| 2026-09-30 | 2026-10-19 | $0.10243 | JSON |
| 2026-10-07 | 2026-10-07 | $0.10243 | JSON |
| 2026-10-14 | 2026-10-15 | $0.10243 | JSON |
| 2026-10-21 | 2026-10-22 | $0.09941 | JSON |
| 2026-10-28 | 2026-10-29 | $0.09941 | JSON |
duloxetine hcl dr 40 mg cap · $0.00000 per EA change since 2026-10-21
NDC 27241016430 · EA · 14 source dates. Missing observations are not interpolated.
| Source date | First retrieved | USD per EA | Snapshot |
|---|---|---|---|
| 2026-01-28 | 2026-10-19 | $1.14933 | JSON |
| 2026-02-25 | 2026-10-19 | $1.14190 | JSON |
| 2026-03-25 | 2026-10-19 | $1.04771 | JSON |
| 2026-04-29 | 2026-10-19 | $1.04655 | JSON |
| 2026-05-27 | 2026-10-19 | $1.07134 | JSON |
| 2026-06-24 | 2026-10-19 | $1.17691 | JSON |
| 2026-07-29 | 2026-10-19 | $1.25271 | JSON |
| 2026-08-26 | 2026-10-19 | $1.37666 | JSON |
| 2026-09-16 | 2026-09-22 | $1.37666 | JSON |
| 2026-09-30 | 2026-10-19 | $1.24391 | JSON |
| 2026-10-07 | 2026-10-07 | $1.24391 | JSON |
| 2026-10-14 | 2026-10-15 | $1.24391 | JSON |
| 2026-10-21 | 2026-10-22 | $1.21471 | JSON |
| 2026-10-28 | 2026-10-29 | $1.21471 | JSON |
duloxetine hcl dr 60 mg cap · $0.00000 per EA change since 2026-10-21
NDC 00228289203 · EA · 14 source dates. Missing observations are not interpolated.
| Source date | First retrieved | USD per EA | Snapshot |
|---|---|---|---|
| 2026-01-28 | 2026-10-19 | $0.09709 | JSON |
| 2026-02-25 | 2026-10-19 | $0.10237 | JSON |
| 2026-03-25 | 2026-10-19 | $0.11362 | JSON |
| 2026-04-29 | 2026-10-19 | $0.12286 | JSON |
| 2026-05-27 | 2026-10-19 | $0.13065 | JSON |
| 2026-06-24 | 2026-10-19 | $0.12954 | JSON |
| 2026-07-29 | 2026-10-19 | $0.12914 | JSON |
| 2026-08-26 | 2026-10-19 | $0.12934 | JSON |
| 2026-09-16 | 2026-09-22 | $0.12934 | JSON |
| 2026-09-30 | 2026-10-19 | $0.13493 | JSON |
| 2026-10-07 | 2026-10-07 | $0.13493 | JSON |
| 2026-10-14 | 2026-10-15 | $0.13493 | JSON |
| 2026-10-21 | 2026-10-22 | $0.13680 | JSON |
| 2026-10-28 | 2026-10-29 | $0.13680 | JSON |
duloxetine hcl dr 90 mg cap · $0.00000 per EA change since 2026-10-21
NDC 52427091330 · EA · 2 source dates. Missing observations are not interpolated.
Get a price for your prescription
- Match the label. Write down the full product name, strength, dosage form, and quantity. Ask the pharmacy about the package if you are unsure.
- Ask for separate totals. Get the cash price, insurance price, and any discount offer for the same fill.
- Include required fees. Add delivery or membership costs that are not already included in the quote.
- Compare and confirm. Use your actual quotes in the calculator and ask your plan about the effect on your benefit.
A question to bring to the counter
“Could you check the cash total and my insurance cost for my prescribed Duloxetine, with the same strength, form, and quantity? Are there any extra fees, and is this the final price for this fill?”
Common questions
How much does Duloxetine cost without insurance?
RxCompare does not have a live retail quote for Duloxetine. Request the cash total for your prescribed strength, form, and quantity from a pharmacy. The table on this page is an acquisition-cost reference, not an amount you can expect to pay.
Can I compare different Duloxetine strengths?
Use the exact prescribed product for a fair price comparison. Do not change strength, form, or release type based on a benchmark; ask your clinician or pharmacist about medication changes.
Why is my pharmacy quote different from this table?
The table reports a dated national acquisition benchmark for one representative NDC per description. Your pharmacy may stock another package or manufacturer, and retail pricing includes more than acquisition cost.
Sources & further reading
Source links checked 2026-09-22. Cost information only; this content has not been clinically reviewed.